Curcumin Increases BDNF and VEGF Levels in the Prefrontal Cortex but not in the Hippocampus in Adolescent Rats Undergoing Exhausting Swimming Exercise
DOI:
https://doi.org/10.5281/zenodo.13118509Keywords:
Neurotrophic factors, Exhaustive exercise, BrainAbstract
Physical exercise during adolescence affects brain functions for a long time, extending into adulthood. This study was aimed to examine the effect of curcumin supplementation on Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) levels in the brain in adolescent rats subjected to weight-loaded forced swimming exercise. Female Sprague-Dawley rats at 6 weeks of age were randomly assigned to four groups: control, swimming exercised (SE), curcumin (CCM) and swimming exercised+curcumin (SE+CCM). After 1 week of adaptation training, SE and SE+CCM groups were given weight-loaded swimming exercise 5 days a week for 4 weeks. Curcumin was administered to rats in CCM SE+CCM groups via intragastric gavage at a dose of 50 mg/kg/d for 5 weeks. Prefrontal cortex and hippocampus BDNF and VEGF levels, and immunoreactivities were evaluated. BDNF levels of the SE group were significantly lower than the control and SE+CCM groups in the prefrontal cortex. VEGF levels of the SE group were significantly lower than the CCM and SE+CCM groups in the prefrontal cortex. VEGF values of the control group was increased compared to the SE and SE+CCM groups in the hippocampus. BDNF and VEGF immunoreactivities of the SE group were significantly lower than the control, CCM and SE+CCM groups. Our study show that curcumin supplementation reduces the inhibitory effect of exhaustive swimming exercise on the neurotrophic factors in the brain. The underlining mechanism of the effect of curcumin is related to BDNF and VEGF levels.
References
Abd-Rabo, M. M., Georgy, G. S., Saied, N. M., & Hassan, W. A. (2019). Involvement of the serotonergic system and neuroplasticity in the antidepressant effect of curcumin in ovariectomized rats: Comparison with oestradiol and fluoxetine. Phytotherapy Research, 33(2), 387–396. https://doi.org/10.1002/ptr.6232
Algaidi, S. A., Eldomiaty, M. A., Elbastwisy, Y. M., Almasry, S. M., Desouky, M. K., & Elnaggar, A. M. (2019). Effect of voluntary running on expression of myokines in brains of rats with depression. International Journal of Immunopathology and Pharmacology, 33,2058738419833533. https://doi.org/10.1177/2058738419833533
Assi, A. A., Farrag, M. M. Y., Badary, D. M., Allam, E. A. H., & Nicola, M. A. (2023). Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease. Inflammopharmacology, 31(3), 1449-1464. https://doi.org/10.1007/s10787-023-01164-6
Bathina, S., & Das, U. N. (2015). Brain-derived neurotrophic factor and its clinical implications. Archives of Medical Science, 11(6), 1164-1178. https://doi.org/10.5114/aoms.2015.56342
Chang, Q., Miao, X., Ju, X., Zhu, L., Huang, C., Huang, T., Zuo, X., & Gao, C. (2013). Effects of pulse current on endurance exercise and its anti-fatigue properties in the hepatic tissue of trained rats. PloS ONE, 8(10), e75093. https://doi.org/10.1371/journal.pone.0075093
Cheriki, M., Habibian, M., & Moosavi, S. J. (2024). Curcumin attenuates brain aging by reducing apoptosis and oxidative stress. Metabolic Brain Disease, https://doi.org/10.1007/s11011-023-01326-z
Dabidi, R. V., Hosseinzadeh, S., Mahjoub, S., Hosseinzadeh, M., & Myers, J. (2013). Endurance exercise training and diferuloyl methane supplement: changes in neurotrophic factor and oxidative stress induced by lead in rat brain. Biology of Sport, 30(1), 41-46. https://doi.org/10.5604/20831862.1029820
Ding, Y., Xie, L., Chang, C. Q., Chen, Z. M., & Ai, H. (2015). Activation of γ-aminobutyric Acid (A) Receptor Protects Hippocampus from Intense Exercise-induced Synapses Damage and Apoptosis in Rats. Chinese Medical Journal, 128(17), 2330-2339. https://doi.org/10.4103/0366-6999.163392
Feizolahi, F., Azarbayjani, M. A., Nasehi, M., Peeri, M., & Zarrindast, M. R. (2019). The combination of swimming and curcumin consumption may improve spatial memory recovery after binge ethanol drinking. Physiology & Behavior, 207, 139–150. https://doi.org/10.1016/j.physbeh.2019.03.018
Gomez-Pinilla, F., & Gomez, A. G. (2011). The influence of dietary factors in central nervous system plasticity and injury recovery. PM&R, 3, S111–S116. https://doi.org/10.1016/j.pmrj.2011.03.001
Guo, C., Yao, Y., Ma, C., Wang, Z. (2023). High-intensity interval training improves cognitive impairment of vascular dementia rats by up-regulating expression of brain-derived neurotrophic factor in the hippocampus. NeuroReport., 34(8), 411-418. https://doi.org/10.1097/WNR.0000000000001903
Hosseinzadeh, S., Roshan, V. D., & Mahjoub, S. (2013). Continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats. Pharmaceutical Biology, 51(2), 240–245. https://doi.org/10.3109/13880209.2012.717230
Jiang, P., Dang, R. L., Li, H. D., Zhang, L. H., Zhu, W. Y., Xue, Y., & Tang, M. M. (2014). The impacts of swimming exercise on hippocampal expression of neurotrophic factors in rats exposed to chronic unpredictable mild stress. Evidence-Based Complementary and Alternative Medicine, Article ID 729827. https://doi.org/10.1155/2014/729827
Kim, M. J., Zhang, T., Kim, K. N., Bae, G. W., Yoon, S. M., Yue, Y., Wu, X., & Park, S. (2022). Alleviation of cognitive and physical fatigue with enzymatic porcine placenta hydrolysate intake through reducing oxidative stress and inflammation in intensely exercised rats. Biology, 11(12), 1739. https://doi.org/10.3390/biology11121739
Krupa, P., Svobodova, B., Dubisova, J., Kubinova, S., Jendelova, P., & Machova Urdzikova, L. (2019). Nano-formulated curcumin (Lipodisq™) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats. Neuropharmacology, 155, 54–64. https://doi.org/10.1016/j.neuropharm.2019.05.018
Lee, D. Y., Im, S. C., Kang, N. Y., & Kim, K. (2023). Analysis of effect of intensity of aerobic exercise on cognitive and motor functions and neurotrophic factor expression patterns in an Alzheimer’s disease rat model. Journal of Personalized Medicine, 13(11), 1622. https://doi.org/10.3390/jpm13111622
Leger, C., Quirié, A., Méloux, A., Fontanier, E., Chaney, R., Basset, C., Lemaire, S., Garnier, P., & Prigent-Tessier, A. (2024). Impact of exercise intensity on cerebral BDNF levels: Role of FNDC5/Irisin. International Journal of Molecular Sciences, 25(2), 1213. https://doi.org/10.3390/ijms25021213
Li, T. G., Shui, L., Ge, D. Y., Pu, R., Bai, S. M., Lu, J., & Chen, Y. S. (2019). Moxibustion reduces inflammatory response in the hippocampus of a chronic exercise-induced fatigue rat. Frontiers in Integrative Neuroscience, 13, 48. https://doi.org/10.3389/fnint.2019.00048
Liu, L., Wu, X., Zhang, B., Yang, W., Li, D., Dong, Y., Yin, Y., & Chen, Q. (2017). Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage. Food & Nutrition Research, 61(1), 1333390. https://doi.org/10.1080/16546628.2017.1333390
Lou, S. J., Liu, J. Y., Chang, H., & Chen, P. J. (2008). Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats. Brain Research, 1210, 48-55. https://doi.org/10.1016/j.brainres.2008.02.080
Nofuji, Y., Suwa, M., Moriyama, Y., Nakano, H., Ichimiya, A., Nishichi, R., Sasaki, H., Radak, Z., & Kumagai, S. (2008). Decreased serum brain-derived neurotrophic factor in trained men. Neuroscience Letters, 437(1), 29-32. https://doi.org/10.1016/j.neulet.2008.03.057
Nowacka, M. M., & Obuchowicz, E. (2012). Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action. Neuropeptides, 46(1), 1–10. https://doi.org/10.1016/j.npep.2011.05.005
Peng, G., Zheng, H., Wu, C., Wu, C., Ma, X., Xiong, J., Hou, J., Zhang, L., Yang, L., & Pan, H. (2021). Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats. Brain Research, 1772, 147665. https://doi.org/10.1016/j.brainres.2021.147665
Petiz, L. L., Girardi, C. S., Bortolin, R. C., Kunzler, A., Gasparotto, J., Rabelo, T. K., Matté, C., Moreira, J. C., & Gelain, D. P. (2017). Vitamin a oral supplementation induces oxidative stress and suppresses IL-10 and HSP70 in skeletal muscle of trained rats. Nutrients, 9(4), 353. https://doi.org/10.3390/nu9040353
Rostami, S., Haghparast, A., & Fayazmilani, R. (2021). The downstream effects of forced exercise training and voluntary physical activity in an enriched environment on hippocampal plasticity in preadolescent rats. Brain Research, 1759, 147373. https://doi.org/10.1016/j.brainres.2021.147373
Shin, I. S., Kim, D. H., Jang, E. Y., Kim, H. Y., & Yoo, H. S. (2019). Anti-fatigue properties of cultivated wild ginseng distilled extract and its active component panaxydol in rats. Journal of Pharmacopuncture, 22(2), 68-74. https://doi.org/10.3831/KPI.2019.22.008
Shirpoor, M., Tofighi, A., Shirpoor, A., Pourjabali, M., & Chodari, L. (2021). Effect of moderate exercises and curcumin on hepatic transcriptional factors associated with lipid metabolism and steatosis in elderly male rat. Research in Pharmaceutical Sciences, 16(3), 294–304. https://doi.org/10.4103/1735-5362.314828
Sokouti, H., Mohajeri, D., & Nourazar, M. A. (2022). 6-Hydroxydopamine-induced neurotoxicity in rat model of Parkinson’s disease: Is reversed via anti-oxidative activities of curcumin and aerobic exercise therapy. Physiological Research, 71(4), 551–560. https://doi.org/10.33549/physiolres.934929
Song, M. K., Kim, E. J., Kim, J. K., Park, H. K., & Lee, S. G. (2019). Effect of regular swimming exercise to duration-intensity on neurocognitive function in cerebral infarction rat model. Neurological Research, 41(1), 37-44. https://doi.org/10.1080/01616412.2018.1524087
Sun, F. Y., & Guo, X. (2005). Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. Journal of Neuroscience Research, 79(1-2), 180–184. https://doi.org/10.1002/jnr.20321
Uysal, N., Kiray, M., Sisman, A. R., Camsari, U. M., Gencoglu, C., Baykara, B., Cetinkaya, C., & Aksu, I. (2015). Effects of voluntary and involuntary exercise on cognitive functions, and VEGF and BDNF levels in adolescent rats. Biotechnic & Histochemistry, 90(1), 55–68. https://doi.org/10.3109/10520295.2014.946968
Wilken, R., Veena, M. S., Wang, M. B., & Srivatsan, E. S. (2011). Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Molecular Cancer, 10, 12. https://doi.org/10.1186/1476-4598-10-12
Yildiran, H., Macit, M. S., & Özata Uyar, G. (2020). New approach to peripheral nerve injury: Nutritional therapy. Nutritional Neuroscience, 23(10), 744-755. https://doi.org/10.1080/1028415X.2018.1554322
Yoon, E. J., Jeong, J., Yoon, E., & Park, D. (2023). The effects of treadmill exercise on brain angiogenesis in ovariectomized rats. Physiological Reports, 11(21), 1-9. https://doi.org/10.14814/phy2.15864
Zadeh, H. J., Roholamini, Z., Aminizadeh, S., & Deh-Ahmadi, M. A. (2023). Endurance training and MitoQ supplementation improve spatial memory, VEGF expression, and neurogenic factors in hippocampal tissue of rats. Journal of Clinical and Translational Research, 9(1), 1–7. http://dx.doi.org/10.18053/jctres.09.202301.001
Zhang, R., Zhao, T., Zheng, B., Zhang, Y., Li, X., Zhang, F., Cen, J., & Duan, S. (2021). Curcumin derivative Cur20 attenuated cerebral ischemic injury by antioxidant effect and HIF-1α/VEGF/TFEB-activated angiogenesis. Frontiers in Pharmacology, 12, 648107. https://doi.org/10.3389/fphar.2021.648107
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